1) Brady still has cystic fibrosis. He still has the genetic mutations he was born with (G551D, DF508).
2) He still takes pancreatic enzymes, special vitamins, and several other prescription meds as a result of being born with CF. His pancreas has suffered "permanent" damage that Kalydeco hasn't corrected.
3) According to the gold standard diagnostic test for CF--the sweat test, Brady no longer diagnoses positive for cystic fibrosis (last test was 17 mmol/L, 17!!! Well within the normal range).
4) Kalydeco has corrected the basic defect of cystic fibrosis in Brady's body (dysfunctional CFTR has now become functional). Functional CFTR leads to thinner mucus, improved mucociliary clearance, and restoration of proper pH in the lungs and digestive tract in the body (CFers typically have an overly acidic environment in their lungs and digestive tract, promoting infection and impairing digestion. Kalydeco restores the body's correct pH, giving the body innate bacterial killing power.).
5) In CT scan, Brady's lungs currently show "No visible damage" and appear to be functioning completely normally.
6) Today, Brady has absolutely no lung or sinus symptoms of CF :)
7) Kalydeco is anticipated to add decades and immeasurable quality to Brady's life.
8) If Brady stops taking Kalydeco, the symptoms of cystic fibrosis will return almost immediately.
So what does that all mean? It means my explanation of Brady's condition just got a lot more complicated...I have caught myself using the following phrase recently because I don't know what else to say: